N-M Chapter 616 Gastric Cancer Medicine?
Chapter 616 Gastric Cancer Medicine?
[Gastric Cancer Drug Technology Roadmap]
[Based on the current actual situation of the host, the generated gastric cancer drug is the fastest development path and has a certain timeliness. If it exceeds the time limit, it will be completely ineffective]
Song He's eyelids twitched, the wishing fountain finally threw something fierce!
The technical diagram is displayed in front of you, with an astonishing amount of content, and densely packed small characters are laid out on the diagram.
But the main thing with many words is the details. Overview of the whole article, there are only three main technical steps in total!
The first step is to screen for special mutant space bacteria!
The technology roadmap directly gives the molecular formulas of the secretions of the three fungi, pointing out that the fungi must be able to secrete these three substances, and they must be found and cultured as soon as possible.
The second step is directed culture in a special culture medium environment!
The technical diagram does not directly inform the composition of the culture solution, but provides a range, listing more than 30 chemical agents and more than 20 Chinese herbal medicines. The cultivation formula needs to be adjusted according to the actual situation of the target fungi.
In the third step, genetic modification completes the final transformation!
This step is mainly to reduce impurities, eliminate some harmful substances secreted by bacteria, and improve the purity of the drug.
Song He immediately clapped his hands loudly and shouted to everyone in the laboratory, "Have a meeting!"
The people in white coats quickly gathered and lined up neatly!
The students just looked confused, while the veterans of the experimental team were as if they were facing a formidable enemy. They knew the temper of their boss, and they must have had something in mind when they suddenly held a meeting!
"The focus of our work is about to shift! We will put the genetic sequencing first and focus on detecting fungal secretions first!" Song He announced.
"For all fungal secretions, no matter the content, write down the molecular formula and hand it over to me as soon as possible!"
"The faster the better. You should have discovered that after all the bacterial samples came back from space, they were accompanied by slight mutations at different speeds. In the first group of bacterial samples, 40% of the mutant strains disappeared in just five days, so in one step Can’t be slow!”
"Teacher, isn't our task genetic sequencing?" Xia Wansan asked, "Aren't we trying to compete with the School of Biotechnology for speed?"
"Our superiors asked us to do gene sequencing in order to find valuable bacterial species." Song He explained, "The secretions of these bacteria have given me a hunch. Judging from the overall mutation direction, there should be several types of bacteria. The secretion I want, now that I have found the direction, I must move forward with all my strength, don’t sacrifice the good to chase the last!”
With a wave of Song He's hand, all the white coats dispersed, and the work in the laboratory completely changed. The genetic sequencing equipment stopped, and a queue began to line up in front of the equipment for testing secretions.
The old members of the experimental team don't have any objections. They are used to having the boss follow his lead. So far, they have not missed the boss's decision-making. They work mindlessly and obey the command, and in the end they can publish and publish without mercy!
But the freshmen gathered at the experimental table in the corner and couldn't help but murmur.
"Why did the teacher suddenly change direction?" Ling Yiyi didn't understand, "We just tied with Sanggong in the last round, and now Sanggong must be sequencing with all his life! If we stop the gene sequencing, why don't we kneel down immediately?"
"The teacher said that he had a hunch. He must have found some research direction that can lead to great results and kill the world?" Xia Wansan said without confidence, "But just because of a hunch, should we turn?"
"Yeah, what's the use of a premonition?" Ling Yiyi complained, "If the premonition doesn't come true in the end, wouldn't we lose in vain? Pu Songchun, what do you think?"
Pu Songchun twisted the beads in his hands and stood in front of the laboratory equipment, waiting for the results. He smiled lightly and said, "It doesn't matter."
Song He moved a chair and sat in the middle of the laboratory, like a big spider lying on a cobweb.
The people in white coats are like spider threads, constantly conveying the latest results to him, and he can sense any disturbance immediately.
A steady stream of fungal secretion data was handed to him. He read it quickly, glanced at it and put it aside. Soon there was a pile of data papers piled next to the chair.
"Experiment Station No. 16, if you make the data more detailed, you may get results over there."
"Experiment Station No. 2 and No. 19, speed up!"
"No. 8! There's something going on! Hold on!"
He shouted a word or two from time to time, and spent the rest of the time silently reading papers on his mobile phone. The content of the paper was naturally related to gastric cancer.
Among all cancers, gastric cancer ranks fourth in lethality, killing 800,000 people worldwide every year!
The most terrible thing is that nearly half of the patients who die from gastric cancer are in China!
The average life expectancy of most people in extremely poor countries is short, and they die early before the age at which cancer is most likely to occur, or the medical level is poor. Because gastric cancer develops without knowing the cause, they are hastily buried and die in a muddle.
As for countries that solve the problem of food and clothing, Western diets are high in sugar and are prone to high-sugar diseases, while Eastern diets are high in salt, so they are prone to high-salt diseases such as gastric cancer.
When Song He saw the data, he knew that gastric cancer medicine was a must. After all, nearly half of the patients were his own people, so the urgency of the matter became high.
The current cure status of gastric cancer is very miserable. If it is discovered in the early stage, the five-year survival rate can reach 70%. However, if it is not discovered until the late stage, the five-year survival rate is only 4%.
Moreover, the main method of cure is simple and crude surgery to remove the tumor. The stomach wall and colon wall are divided into five layers. Early gastric cancer will hardly metastasize. As for the gastric cancer drugs currently in use on the market, their effects are quite limited. There are no drugs that can cure the disease, so they can only delay the treatment.
Song He scratched his head and quickly read the mature gastric cancer drugs on the market as a reference.
Apatinib, domestically produced and self-developed, is the world’s first safe and effective targeted drug for advanced gastric cancer. It is also the only oral preparation currently available. It is used for advanced patients who have failed second-line chemotherapy. It can prolong life for a period of time, but has many side effects. Granulocytes The white blood cells and platelets all dropped, and I had diarrhea, abdominal pain and general fatigue.
Trastuzumab has significant efficacy, but 15% of patients cannot use it, and it is accompanied by strong side effects such as rash, anemia, myalgia, and cardiotoxicity.
Ramucirumab has fewer side effects, but its efficacy is only slightly better than placebo.
[Biological progress detected, from Master Level 30 to Master Level 31! 】
Fluorouracil carbamate, Tegafur, Germost...
Otiracil, paclitaxel polymer, oxaliplatin...
[Biological progress detected, from Master Level 31 to Master Level 32! 】
Larotinib, entrectinib, seputinib...
Putelimab, slulimumab, vedicitumab…
[Biological progress detected, from Master Level 32 to Master Level 33! 】
After five consecutive days of hard work, the secretions of the second batch of space bacteria were finally measured, and the data sheets piled up like mountains!
However, none of the three secretions Song He wanted appeared!
He could only order the experimental team to retest from scratch. After all, space bacteria are always changing, and special mutations may appear at some point in time. As for the gene sequencing of fungi, it has not been uploaded for several days.
On weekend night, bad news came.